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パーキンソン病センター

研究成果

(2000年以降発表分)

Sawada H, Ibi M, Kihara T, Urushitani M, Nakanishi M, Akaike A, Shimohama S. Neuroprotective Mechanism of GDNF in Mesencephalic Neurons. J. Neurochem. 74: 1175-1184, 2000

Sawada H, Udaka F, Izumi Y, Nishinaka K, Kawakami H, Nakamura S, Kameyama M. Cerebral white matter lesions are not associated with apo E genotype but with age and female gender in Alzheimer’s disease. J. Neurol. Neurosurg. Psych. 68: 653-656, 2000

Sawada H, Ibi M, Kihara T, Urushitani M, Honda K, Nakanishi M, Akaike A, Shimohama S. Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons. FASEB J. 14: 1202-1214, 2000

Honda K, Sawada H, Kihara T, Urushitani M, Nakamizo T, Akaike A, Shimohama S. Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. J Neurosci Res. 60: 321-327, 2000

Urushitani M, Inoue R, Nakamizo T, Sawada H, Shibaski H, Shimohama S. Neuroprotective effect of cyclic GMP against radical-induced toxicity in cultured spinal motor neurons. J Neurosci. Res. 61: 443-448, 2000

Nakamizo T, Urushitani M, Inoue R, Shinohara A, Sawada H, Honda K, Kihara T, Akaike A, Shimohama S. Protection of cultured spinal motor neurons by estradiol. Neuroreport 11: 3493-3497, 2000

Urushitani M, Inoue R, Sawada H, Kihara T, Honda K, Akaike A, Shimohama S. N-methyl-D-aspartate receptor-mediated mitochondrial Ca2+-overload in acute excitotoxic neuronal death: A mechanism distinct from chronic neurotoxicity after Ca2+ influx. J. Neurosci. Res. 63: 377-387, 2001

Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A. α7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block Aβ-amyloid-induced neurotoxicity. J. Biol. Chem. 276: 13541-13546, 2001

Ibi M, Sawada H, Nakanishi M, Kume T, Katsuki H, Kaneko S, Shimohama S. Akaike A. Protective effects of 1 α, 25-(OH)2D3 against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. Neuropharmacology 40:761-771, 2001

Honda K, Shimohama S, Sawada H, Kihara T, Nakamizo T, Shibasaki S. Akaike A. Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. J. Neurosci. Res. 64: 466-475, 2001

Nakamizo T, Inoue H, Udaka F, Oda M, Kawai M, Uemura K, Takahashi M, Nishinaka K, Sawada H, Kameyama M, Koyama T. Magnetic resonance imaging of primary spinal intramedullary lymphoma. J. Neuroimaging 12: 183-186, 2002

Sawada H, Ibi M, Kihara T, Honda K, Nakamizo T, Kanki R, Nakanishi M, Sakka N, Akaike A, Shimohama S. Estradiol protects dopaminergic neurons in a MPP+ Parkinson’s disease model. Neuropharmacology 42: 1056-1064, 2002

Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Kanki R, Yamashita H, Akaike A. Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. J. Neurosci. Res. 70: 274-282, 2002

Udaka F, Sawada H, Kameyama M. White matter lesions and dementia: MRI-pathological correlation. Ann. N. Y. Acad. Sci. 977:411-415, 2002

Nakamizo T, Kawamata J, Yoshida K, Kawai Y, Kanki R, Sawada H, Kihara T, Yamashita H, Shibassaki H, Akaike A, Shimohama S. Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons. J. Neurosci. Res. 71: 485-495, 2003

Sakka N, Sawada H, Izumi Y, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A. Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone. Neuroreport 14: 2425-2428, 2003

Inden M, Kondo J, Kitamura Y, Takata K, Tsuchiya D, Nishimura K, Taniguchi T, Sawada H, Shimohama S. Differences in rotational asymmetry in rats caused by single intranigral injections of 6-hydroxydopamine, 1-methyl-4-phenylpyridinium ion and rotenone. Biogenic Amines 17: 281-291, 2003

Shinde A, Nakano S, Kusaka H, Nakaya Y, Sawada H, Kohara N, Shibasaki H. Nucleolar characteristics of reducing bodies in reducing body myopahty. Acta Neuropathol. 107: 265-271, 2004

Sawada H, Kohno R, Kihara T, Izumi Y, Sakka N, Ibi M, Nakanishi M, Nakamizo T, Yamakawa K, Shibasaki H, Yamamoto N, Akaike A, Inden M, Kitamura Y, Taniguchi T, Shimohama S. Proteasome mediates dopaminergic neuronal degeneration, and its inhibition cuases α-synuclein inclusions. J. Biol. Chem. 279: 10710-10719, 2004

Kohno R, Sawada H, Kawamoto Y, Uemura K, Shibasaki H, Shimohama S. BDNF is induced by wild-type α-synuclein but not by the two mutants, A30P or A53T, in glioma cell line. Biochem. Biophys. Res. Commun. 318: 113-118, 2004

Kanki R, Nakamizo T, Yamashita H, Kihara T, Sawada H, Uemura K, Kawamata J, Shibasaki H, Akaike A, Shimohama S. Effects of mitochondrial dysfunction on glutmate receptor-mediated neurotoxicity in cultured rat spinal motor neurons. Brain Res. 1015: 73-81, 2004

Kihara T, Sawada H, Nakamizo T, Kanki R, Yamashita H, Maelicke A, Shimohama S. Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity. Biochem Biophys Res Commun. 325: 976-982, 2004

Inden M, Kondo JI, Kitamura Y, Takata K, Nishimura K, Taniguchi T, Sawada H, Shimohama S. Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats. J Pharmacol. Sci. 97: 203-211, 2005

Sawada H, Yamakawa K, Yamakado H, Hosokawa R, Ohba M, Miyamoto K, Kawamura T, Shimohama S. Cocaine and phenylephrine eye drop test for Parkinson disease. JAMA 293: 932-934, 2005

Izumi Y, Sawada H, Sakka N, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A. p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly J Neurosci Res 79: 849-860, 2005.

Nakamizo T, Kawamata J, Yamashita H, Kanki R, Kihara T, Sawada H, Akaike A, Shimohama S. Stimulation of nicotinic acetylcholine receptors protects motor neurons. Biochem Biophys Res Commun 330: 1285-1289, 2005

Kume T, KawaiY, Yoshida K, Nakamizo T, Kanki R, Sawada H, Katsuki H, Shimohama S, Sugimoto H, Akaike A. Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons. Neurosci Lett 382: 199-202, 2005

Izumi Y, Sawada H, Yamamoto N, Kume T, Katsuki H, Shimohama S. Akaike A. Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells. J Neurosci Res 82: 126-137, 2005

Ueki Y, Mima T, Kotb MA, Sawada H, Saiki H, Ikeda A, Begum T, Reza F, Nagamine T, Fukuyama H. Altered plasticity of the human motor cortex in Parkinson’s disease. Ann Neurol 59: 60-71, 2006

Ihara M, Makino F, Sawada H, Mezaki T, Mizutani K, Nakase H, Matsui M, Tomimot H, Shimohama S. Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia. Intern Med 45: 135-140, 2006

Begum T, Ikeda A, Yoshioka A, Sawada H, Fukuyama H, Shibasaki H. Rapid recovery from coma with multifocal PLEDs in a patient with severe dementia and transient hypoxemia. Intern Med 45: 823-826, 2006

Yamamoto N, Sawada H, Izumi Y, Kume T, Katsuki H, Shimohama S, Akaike A. Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: Relevance to Parkinson disease. J Biol Chem 282: 4364-72, 2007

Izumi Y, Sawada H, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A. Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity. Eur J Pharmacol 557: 132-140, 2007

Takeuchi H, Yanagida T, Inden M, Takata K, Kitamura K, Yamakawa K, Sawada H, Izumi Y, Yamamoto N, Kihara T, Uemura K, Inoue H, Taniguchi T, Akaike A, Takahashir R, Shimohama S.  Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Pakrinson’s disease model. J Neurosci Res (in press)

Sawada H, Oeda T, Yamamoto K, Kitagawa N, Hosokawa R, Ohba M, Nishio R, Yamakawa K, Takeuchi H, Shimohama S, Takahashi R, Kawamura T. Diagnostic accuracy of cardiac metaiodobenzylguanidine (MIBG) scintigraphy in Parkinson disease. Eur J Neurol (in press)

Oeda T, et al. High risk factors for valvular heart disease from dopamine agonists in patients with Parkinson's disease. J Neural Trans (in press)